Our laboratory is interested in elucidating the pathogenic mechanisms underlying neurological disorders that impact learning and memory and to identify new therapeutic targets and candidate therapeutics. We study disease pathogenesis both on the cellular and on the systems level, using a multidisciplinary approach that combines molecular biology and electrophysiology with computational biology and bioengineering.
Our main approaches are:
- Studying disease-associated changes on the genomic level through transcriptomic and epigenomic analysis to identify cell types and cellular processes involved in pathogenesis. Learn More.
- Unraveling the mechanisms underlying the effects of specific disease-associated genes or gene variants with the help of sophisticated and highly tractable in vitro models. Learn More.
- Analyzing system- and circuit-level disease characteristics and studying the effect of system- or circuit-level manipulations on disease phenotypes in animal models. Learn More.